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Why Suboxone is the gold standard for MAT and superior to methadone

The opioid crisis has led to increased focus on effective treatments for opioid addiction. Among these, Methadone and Suboxone are prominent. While Methadone has been used for decades, Suboxone is increasingly preferred in many cases. This post will explore why Suboxone is considered the gold standard, particularly in terms of its lower potential for addiction, comparing it with Methadone's more addictive nature.

Pharmacology of Methadone and Suboxone

Methadone is a long-acting opioid agonist, which means it activates the same opioid receptors in the brain as other opioids like heroin or prescription painkillers. Its long action is beneficial for reducing withdrawal symptoms and cravings. However, this same mechanism contributes to its potential for addiction.

Suboxone, on the other hand, is a combination of buprenorphine and naloxone. Buprenorphine is a partial opioid agonist, which activates opioid receptors but to a lesser extent than full agonists like methadone. This property reduces the risk of misuse, dependence, and side effects. Naloxone is an opioid antagonist, added to deter intravenous misuse of Suboxone.

Effectiveness in Treating Opioid Dependence

Several studies have shown that both Methadone and Suboxone are effective in treating opioid dependence. However, Suboxone offers certain advantages. Its ceiling effect due to the partial agonist action of buprenorphine means there is a limit to the euphoria it can produce, reducing the risk of misuse. Moreover, Suboxone’s formulation with naloxone makes it less appealing for those seeking to abuse it intravenously.

Addiction Potential and Safety Profile

Methadone, being a full opioid agonist, has a higher potential for addiction. Patients on Methadone maintenance often require long-term treatment and are at risk of developing a secondary addiction to Methadone itself. In contrast, Suboxone’s partial agonist property makes it less likely to induce a secondary addiction. The risk of overdose is also lower with Suboxone, as its effects plateau at higher doses, providing a safety buffer not present with Methadone.

Social and Clinical Implications

The choice between Methadone and Suboxone also has social implications. Methadone treatment usually requires daily visits to specialized clinics, which can be stigmatizing and inconvenient. Suboxone, being less prone to abuse, can be prescribed in a doctor’s office and taken at home, offering more privacy and convenience. This accessibility can significantly improve adherence to treatment and overall recovery outcomes. Most importantly, Suboxone can be accessed and administered via telehealth at Step Free Recovery.


While both Methadone and Suboxone are effective in treating opioid dependence, Suboxone’s lower potential for addiction, safety profile, and convenience make it a superior choice in many cases. Its formulation limits abuse potential and provides a safer option for long-term treatment, addressing the concern of substituting one addiction for another, which is more pronounced with Methadone.


Substance Abuse and Mental Health Services Administration (SAMHSA). Guidelines for the Use of Buprenorphine in the Treatment of Opioid Addiction.

World Health Organization (WHO). Guidelines for the Psychosocially Assisted Pharmacological Treatment of Opioid Dependence.

National Institute on Drug Abuse (NIDA). Research on the Treatment of Opioid Addiction.

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